Super Mana Potion

Mana sickness punishes how often you drink, not how much you get back. If your weapon burns through a pool slowly enough that you are already spacing sips out comfortably, the bigger bottle buys you nothing and costs a great deal more to make. The upgrade only pays for itself on weapons that empty you in a couple of seconds, the ones that would otherwise leave you drinking constantly and living under a permanent damage penalty.

An alchemy station gives every ingredient a chance to survive the craft, and on a potion this expensive that saving compounds fast. The unicorn horns and crystal shards are the parts you have to go and collect, so mixing these anywhere else quietly throws away trips into the Hallow.

Mana regeneration accessories and a sanely priced weapon will keep you firing without a bottle in hand at all. Reach for this tier when the build is deliberately expensive, not by default.