Ankh Charm

The list of things it blocks reads long, but in practice you are buying protection from a handful of specific disasters. Cursed shuts your weapons off completely. Silenced does the same to magic. Confused reverses your movement controls at the worst possible moment. Broken Armor strips your defense right when something big is winding up. Any one of those landing mid boss is what ends a run. The rest of the list is background noise.

It wipes existing debuffs the instant it goes on, and that is the whole trick. Park it in a spare loadout or a vanity slot, keep something with a real stat in the live slot, and swap across only when something you need gone actually lands. You give up nothing by leaving it on the bench, because it does no work at all until a debuff arrives.

This is one half of the Ankh Shield, so if you are building toward that you will assemble it on the way regardless. Do not sit on the components waiting for a reason. None of them have another use, and the charm costs nothing to put together once you have them.