Web Covered Chest

The Web Slinger is the reason to look for one. Every single chest of this type holds it, so finding one in a Spider Nest is the dependable way to get a hook that fires several lines at once, and that hook stays in your build long after the rest of the contents stop mattering.

Everything else inside is drawn from the same pool as an ordinary Gold Chest, shifted a little by how deep you found it. Nothing in there is exclusive, so once you have the hook there is no reason to keep hunting nests for chests specifically.

They are genuinely rare within a nest, so plan on clearing the whole cave rather than checking a room or two. Bring something that cuts cobweb fast: the webs kill your momentum and the chest is easy to walk straight past in the clutter.